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Martha Nelson Lab

  • Research
    • H5N1 and highly pathogenic avian influenza
    • Swine influenza
    • Human influenza
    • Other influenza
    • SARS-CoV-2 in non-human reservoirs
    • SARS-CoV-2 in humans
    • Other disease systems
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  • Martha Nelson, Ph.D.

    Martha Nelson is a computational biologist studying pathogen evolution in the Division of Intramural Research at the National Institutes of Health and an adjunct associate professor of global health at Georgetown University.

    Background

    Dr. Nelson has led the Virus Evolution Lab at the National Institutes of Health (opens in a new tab) (NIH) since January 2026. She is a Stadtman Tenure-Track Investigator in the Division of Intramural Research at the National Library of Medicine (NLM), located on the NIH main campus in Bethesda, Maryland.

    She has a joint appointment at the Laboratory of Viral Diseases in the National Institute for Allergy and Infectious Diseases (NIAID). Dr. Nelson also is an Adjunct Associate Professor at Georgetown University (opens in a new tab), in the Global Infectious Diseases graduate program.

    Prior to joining NLM/NIAID, Dr. Nelson was a co-leader of the MISMS influenza research network at the Fogarty International Center, which trained hundreds of scientists around the world in methods of phylodynamic analysis of pathogen genome data.

    Dr. Nelson remains an active collaborator in NIAID’s extramurally funded Centers of Excellence in Influenza Research and Response (opens in a new tab) (CEIRR) network, an international influenza research network that has studied pandemic risks for over 20 years.

    She received her Ph.D. in biology from Penn State University’s Center for Infectious Disease Dynamics (CIDD) and B.A. in biology from Amherst College.

    No photograph available for Martha I. Nelson, Ph.D.

    Affiliations

    • Division of Intramural Research, National Institutes of Health
    • Adjunct associate professor, Georgetown University, 2022 to present

    Profiles

    • ORCID (opens in a new tab)
    • Google Scholar (opens in a new tab)
    • ResearchGate (opens in a new tab)
    • LinkedIn (opens in a new tab)
    • Twitter / X (opens in a new tab)
    • NIH faculty bio (opens in a new tab)
    • Georgetown faculty bio (opens in a new tab)
    • The Scientist (opens in a new tab)
    • Kudos (opens in a new tab)

    Contact

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    Select publications

    ★ Featured publication

    Can H5N1 avian influenza in dairy cattle be contained in the US?

    Pekar JE, Crespo-Bellido A, Lemey P, Bowman AS, Peacock TP, Ochoa JN, Rambaut A, Pybus OG, Worobey M, Nelson MI

    Cell · 2026 · 189(3):699-705

    H5N1 and highly pathogenic avian influenza Review

    Full text for “Can H5N1 avian influenza in dairy cattle be contained in the US?”: Publisher (opens in a new tab) PubMed (opens in a new tab)

    ★ Featured publication

    SARS-CoV-2 Delta variant re-emerges in US farmed mink and free-ranging white-tailed deer in 2022-2023

    Crespo-Bellido A, Owsiany MC, Chillson NN, Huey D, McBride DS, Lemey P, Rekant SI, Korslund J, Neafsey M, Killian ML, Chandler JC, Hobbs C, Hildebrandt HH, Easley J, Yount JS, Nelson MI, Bowman AS

    Nat Commun · 2026 · 17(1)

    SARS-CoV-2 in non-human reservoirs

    Full text for “SARS-CoV-2 Delta variant re-emerges in US farmed mink and free-ranging white-tailed deer in 2022-2023”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations

    Pardo-Roa C, Nelson MI, Ariyama N, Aguayo C, Almonacid LI, Gonzalez-Reiche AS, Muñoz G, Ulloa M, Ávila C, Navarro C, Reyes R, Castillo-Torres PN, Mathieu C, Vergara R, González Á, González CG, Araya H, Castillo A, Torres JC, Covarrubias P, Bustos P, van Bakel H, Fernández J, Fasce RA, Johow M, Neira V, Medina RA

    Nat Commun · 2025 · 16(1):2232

    H5N1 and highly pathogenic avian influenza

    Full text for “Cross-species and mammal-to-mammal transmission of clade 2.3.4.4b highly pathogenic avian influenza A/H5N1 with PB2 adaptations”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    The global H5N1 influenza panzootic in mammals

    Peacock TP, Moncla L, Dudas G, VanInsberghe D, Sukhova K, Lloyd-Smith JO, Worobey M, Lowen AC, Nelson MI

    Nature · 2025 · 637(8045):304-313

    H5N1 and highly pathogenic avian influenza Review

    Full text for “The global H5N1 influenza panzootic in mammals”: Publisher (opens in a new tab) PubMed (opens in a new tab)

    ★ Featured publication

    SARS-CoV-2 infection in free-ranging white-tailed deer

    Hale VL, Dennis PM, McBride DS, Nolting JM, Madden C, Huey D, Ehrlich M, Grieser J, Winston J, Lombardi D, Gibson S, Saif L, Killian ML, Lantz K, Tell RM, Torchetti M, Robbe-Austerman S, Nelson MI, Faith SA, Bowman AS

    Nature · 2022 · 602(7897):481-486

    SARS-CoV-2 in non-human reservoirs

    Full text for “SARS-CoV-2 infection in free-ranging white-tailed deer”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Tracing the Source of Influenza A Virus Zoonoses in Interconnected Circuits of Swine Exhibitions

    McBride DS, Perofsky AC, Nolting JM, Nelson MI, Bowman AS

    J Infect Dis · 2021 · 224(3):458-468

    Swine influenza

    Full text for “Tracing the Source of Influenza A Virus Zoonoses in Interconnected Circuits of Swine Exhibitions”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Origins of the 2009 H1N1 influenza pandemic in swine in Mexico

    Mena I, Nelson MI, Quezada-Monroy F, Dutta J, Cortes-Fernández R, Lara-Puente JH, Castro-Peralta F, Cunha LF, Trovão NS, Lozano-Dubernard B, Rambaut A, van Bakel H, García-Sastre A

    Elife · 2016 · 5

    Swine influenza

    Full text for “Origins of the 2009 H1N1 influenza pandemic in swine in Mexico”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Reassortment in segmented RNA viruses: mechanisms and outcomes

    McDonald SM, Nelson MI, Turner PE, Patton JT

    Nat Rev Microbiol · 2016 · 14(7):448-60

    Other disease systems Review

    Full text for “Reassortment in segmented RNA viruses: mechanisms and outcomes”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Global migration of influenza A viruses in swine

    Nelson MI, Viboud C, Vincent AL, Culhane MR, Detmer SE, Wentworth DE, Rambaut A, Suchard MA, Holmes EC, Lemey P

    Nat Commun · 2015 · 6:6696

    Swine influenza

    Full text for “Global migration of influenza A viruses in swine”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Reverse zoonosis of influenza to swine: new perspectives on the human-animal interface

    Nelson MI, Vincent AL

    Trends Microbiol · 2015 · 23(3):142-53

    Swine influenza Review

    Full text for “Reverse zoonosis of influenza to swine: new perspectives on the human-animal interface”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Multiyear persistence of 2 pandemic A/H1N1 influenza virus lineages in West Africa

    Nelson MI, Njouom R, Viboud C, Niang MN, Kadjo H, Ampofo W, Adebayo A, Tarnagda Z, Miller MA, Holmes EC, Diop OM

    J Infect Dis · 2014 · 210(1):121-5

    Human influenza

    Full text for “Multiyear persistence of 2 pandemic A/H1N1 influenza virus lineages in West Africa”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918

    Nelson MI, Viboud C, Simonsen L, Bennett RT, Griesemer SB, St George K, Taylor J, Spiro DJ, Sengamalay NA, Ghedin E, Taubenberger JK, Holmes EC

    PLoS Pathog · 2008 · 4(2):e1000012

    Human influenza

    Full text for “Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918”: Publisher (opens in a new tab) PubMed (opens in a new tab) PMC (opens in a new tab)

    ★ Featured publication

    The evolution of epidemic influenza

    Nelson MI, Holmes EC

    Nat Rev Genet · 2007 · 8(3):196-205

    Human influenza Review

    Full text for “The evolution of epidemic influenza”: Publisher (opens in a new tab) PubMed (opens in a new tab)
    All publications

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